Comments on: Analysis: Cell-cycle-regulated proteins are more abundant in haploid relative to diploid cells http://larsjuhljensen.wordpress.com/2008/09/30/analysis-cell-cycle-regulated-proteins-are-more-abundant-in-haploid-relative-to-diploid-cells/ A computational biologist cleans up his disk Tue, 11 Aug 2009 16:17:51 +0000 http://wordpress.com/ hourly 1 By: Lars Juhl Jensen http://larsjuhljensen.wordpress.com/2008/09/30/analysis-cell-cycle-regulated-proteins-are-more-abundant-in-haploid-relative-to-diploid-cells/#comment-106 Lars Juhl Jensen Tue, 11 Aug 2009 07:30:40 +0000 http://larsjuhljensen.wordpress.com/?p=243#comment-106 Import from FriendFeed: Thomas Lemberger, Bill Hooker, Deepak Singh and Pedro Beltrao liked this. The coverage they got is impressive. I would be more interested in post-translational modifications at this points :) - Pedro Beltrao I agree, the coverage is excellent but it would have been even more interesting if one could compare PTMs between the conditions. Also, I would have liked to see microarray data for the exact same samples; I wonder how much that would improve the agreement between mRNA and protein levels. - Lars Juhl Jensen Did a few tests for correlation of haploid/diploid ratio with other properties: CDK substrates, phosphoproteins, ubiquitinated proteins, D box motifs, KEN box motifs, PEST regions, and phenotype screens. Found weak correlations for ubiquitinated proteins and PEST containing proteins, but these correlations are not statistically significant after correction for multiple testing. - Lars Juhl Jensen Import from FriendFeed:

Thomas Lemberger, Bill Hooker, Deepak Singh and Pedro Beltrao liked this.

The coverage they got is impressive. I would be more interested in post-translational modifications at this points :) – Pedro Beltrao

I agree, the coverage is excellent but it would have been even more interesting if one could compare PTMs between the conditions. Also, I would have liked to see microarray data for the exact same samples; I wonder how much that would improve the agreement between mRNA and protein levels. – Lars Juhl Jensen

Did a few tests for correlation of haploid/diploid ratio with other properties: CDK substrates, phosphoproteins, ubiquitinated proteins, D box motifs, KEN box motifs, PEST regions, and phenotype screens. Found weak correlations for ubiquitinated proteins and PEST containing proteins, but these correlations are not statistically significant after correction for multiple testing. – Lars Juhl Jensen

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